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Anti-CoREST (rabbit polyclonal IgG)

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货号：07-455

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R ICC, IHC, IP, WB, ChIP Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-455
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-CoREST Antibody
Background Information The CoREST gene encodes a functional corepressor required for regulation of neural specific gene expression. REST (RE1 silencing transcription factor 1) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long term gene silencing using a distinct functional complex. Silencing of neuronal specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST response elements.
References
Product Information
Format Purified
Control
  • Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Presentation Protein A Purified immunoglobulin in 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, and 0.05% sodium azide as a preservative.
Applications
Application Detect CoREST with Anti-CoREST Antibody (Rabbit Polyclonal Antibody), that has been shown to work in ChIP, ICC, IHC, IP & WB.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blotting
  • Chromatin Immunoprecipitation (ChIP)
Biological Information
Immunogen GST fusion protein corresponding to residues 109-293 of human CoREST.
Host Rabbit
Specificity Recognizes CoREST.
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The RCOR gene encodes a functional corepressor required for regulation of neural-specific gene expression.[supplied by OMIM]
Gene Symbol
  • RCOR1
  • COREST
  • KIAA0071
  • RCOR
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UKL0 # Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of AOF2/LSD1 on core histones and nucleosomal substrates. It also protects AOF2/LSD1 from the proteasome.
SIZE: 482 amino acids; 53028 Da
SUBUNIT: Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF complex. Interacts directly with herpes virus HSV-1 ICP0 protein, leading to the disruption of the BHC complex, thereby preventing the BHC complex to repress transcription of viral genes.
SUBCELLULAR LOCATION: Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.TISSUE SPECIFICITY: Ubiquitously expressed.DOMAIN:SwissProt: Q9UKL0 The SANT domains may bridge the nucleosomal substrates and the demethylase AOF2/LSD1.
PTM: Phosphorylated by HSV-1 protein kinases in case of infection.
SIMILARITY: Belongs to the CoREST family. & Contains 1 ELM2 domain. & Contains 2 SANT domains.
Molecular Weight 66 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot in RIPA lysates from A431, 3T3/A31, Jurkat,and Hela cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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