Anti-HuR (rabbit polyclonal)

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Anti-HuR (rabbit polyclonal)

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货号：07-468

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	IP, WB, ICC	Rb	Purified	Polyclonal Antibody

Description
Catalogue Number	07-468
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-HuR Antibody
Alternate Names	ELAV-like protein 1 Hu-antigen R
Background Information	HuR (Hu-antigen R, ELAV-like protein 1, ELAV1) is an RNA binding protein that contains 3 RNA-binding domains. It is known to binds AU-rich elements if mRNA. It regulates gene expression by destabilizing their mRNA. It is known to be upregulated in certain cancers such as breast and gastric cancers. Some of its targets include cFos, IL-3, and BRCA1 mRNAs. HuR has also been shown to be involved in the regulation of VEFG-A and NFkB expression in certain cell types. It activation and accumulation are also linked to many energy signaling molcules such as that of the PI3K/Akt pathway and AMPK..

References

Product Information
Format	Purified
Control	3T3/A31 cell lysate
Presentation	See datasheet for exact formulation.

Applications
Application	Anti-HuR Antibody is a Rabbit Polyclonal Antibody for detection of HuR also known as ELAV-like protein 1, Hu-antigen R & has been validated in IP, WB, ICC.
Key Applications	Immunoprecipitation Western Blotting Immunocytochemistry
Application Notes	Immunoprecipitation Analysis: 10 µg from a representative lot detected HuR in RIPA lysate. Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected HuR in HeLa and NIH/3T3 cell lysates. Immunohistochemistry Analysis: This antibody has been reported by an independent laboratory to detect HuR in rabbit placental tissue.

Biological Information
Immunogen	KLH-conjugated, synthetic peptide corresponding to amino acids 1-13 of human HuR.
Host	Rabbit
Specificity	HuR
Species Reactivity	Human Mouse
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_001410
Entrez Gene Summary	The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.
Gene Symbol	ELAVL1 MelG HUR ELAV1 HuR Hua
Purification Method	See datasheet for specific purification method.
UniProt Number	Q15717
UniProt Summary	FUNCTION: SwissProt: Q15717 # Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. SIZE: 326 amino acids; 36092 Da SUBUNIT: Interacts with ANP32A. TISSUE SPECIFICITY: Ubiquitous. PTM: Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge. SIMILARITY: SwissProt: Q15717 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains.
Molecular Weight	~36 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Western Blot Analysis: Evaluated by Western Blot in 3T3/A31 cell lysate using 1 µg/mL of antibody and 10 µg of lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.