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Anti-Pals1 (rabbit immunoaffinity purified IgG)

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货号：07-708

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ca, R IP, WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-708
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Pals1 Antibody
References
Product Information
Format Affinity Purified
Applications
Application Detect Pals1 using this Anti-Pals1 Antibody validated for use in IP, WB & IC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen KLH-conjugated, synthetic peptide (C-YNANKNDDYDNE) corresponding to amino acids 450-461 of human Pals1 (palmitoylated 5 protein), also known as MAGUK p55 subfamily member 5 and stardust (Drosophila). The immunizing sequence is identical in orangutan, chimpanzee, chicken, mouse, rat, canine and fish.
Host Rabbit
Specificity Recognizes Pals1
Isotype IgG
Species Reactivity
  • Canine
  • Rat
Species Reactivity Note Predicted to cross-react with human, orangutan, chimpanzee, mouse, chicken and fish based on sequence homology
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001 [PubMed 11311936]). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM]
Gene Symbol
  • MPP5
  • FLJ12615
  • PALS1
  • stardust
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q8N3R9 # May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of VIL2 to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).
SIZE: 675 amino acids; 77294 Da
SUBUNIT: Interacts with the LIN7 proteins, CRB3 and MPDZ. Interacts with INADL, PARD6B, SC6A1 and VIL2 (By similarity). Forms a complex with CRB1 and MPP4. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3.
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Intracytoplasmic membrane; Peripheral membrane protein. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membranes (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Localized to the Purkinje cell body and axon.
TISSUE SPECIFICITY: Expressed in the retina (at protein level).DOMAIN:SwissProt: Q8N3R9 The L27 domain 1 functions in targeting to the tight junctions by binding to INADL (By similarity). & The PDZ domain binds to the C-terminus of SC6A1 (By similarity).
SIMILARITY: Belongs to the MAGUK family. & Contains 1 guanylate kinase-like domain. & Contains 2 L27 domains. & Contains 1 PDZ (DHR) domain. & Contains 1 SH3 domain.
Molecular Weight Mr 77kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at -20°C from date of shipment
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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