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Anti-phospho-Kip1 (Thr187)

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货号：06-996

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-996
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-phospho-Kip1 (Thr187) Antibody
References
Product Information
Format Affinity Purified
Presentation 0.2M Tris, 0.15 M NaCl, 0.1mM EDTA, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-phospho-Kip1 (Thr187) Antibody is a high quality Rabbit Polyclonal Antibody for the detection of phospho-Kip1 (Thr187) & has been validated in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated, synthetic peptide (C-PNAGSVEQ[pT]PKK) corresponding to amino acids 179-190 of human Kip1
Host Rabbit
Specificity phosphorylated Kip1
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Gene Symbol
  • CDKN1B
  • p27Kip1
  • P27KIP1
  • MEN1B
  • MEN4
  • CDKN4
  • KIP1
Modifications
  • Phosphorylation
Purification Method Immunoaffinity Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P46527 # Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import (By similarity).
SIZE: 198 amino acids; 22073 Da
SUBUNIT: Interacts with NUP50 and with UHMK1. Interacts with COPS5 subunit of COP9 signalosome complex, leading to its subsequent degradation (By similarity). Interacts with SPDYA and is found in a complex with both SPDYA and CDK2.
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Nuclear and cytoplasmic in quiescent cells. Upon cell cycle progression, mostly cytoplasmic (By similarity).
TISSUE SPECIFICITY: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
DOMAIN: SwissProt: P46527 A peptide sequence containing only AA 28-79 retains substantial KIP1 cyclin A/CDK2 inhibitory activity.
PTM: Phosphorylation on Ser-10 leads to nuclear export to the cytoplasm and promotes cell cycle progression (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE: SwissProt: P46527 # Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:610755]. Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.
SIMILARITY: Belongs to the CDI family.
Molecular Weight 27kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on a HeLa cell RIPA lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at -20°C
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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