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Anti-20S proteasome subunit b6

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货号：09-279

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, Rb WB, IHC Rb Serum Polyclonal Antibody
Description
Catalogue Number 09-279
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-20S proteasome subunit β6 Antibody
Alternate Names
  • C5
References
Product Information
Format Serum
Presentation 100 µL of purified antiserum in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Applications
Application Detect 20S proteasome subunit β6 using this Anti-20S proteasome subunit β6 Antibody validated for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Biological Information
Immunogen Peptide corresponding to residues 185-198 of human proteasome subunit β6 conjugated to KLH.
Host Rabbit
Specificity Recognizes proteasome subunit β6
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rabbit
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species.
Gene Symbol
  • PSMB1
  • FLJ25321
  • HC5
  • KIAA1838
  • PSC5
  • PMSB1
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P20618 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
SIZE: 241 amino acids; 26489 Da
SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
SIMILARITY: SwissProt: P20618 ## Belongs to the peptidase T1B family.
Molecular Weight 26 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of shipment for up to 12 months.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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