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Anti-Meis 1/2/3, clone 9.2.7 (mouse ascites IgG1 )

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货号：05-779

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB, IHC M Ascites Monoclonal Antibody
Description
Catalogue Number 05-779
Replaces MABN1071
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Meis 1/2/3 Antibody, clone 9.2.7
Background Information Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Meis1, 2, and 3 are members of the TALE (three amino acid loop extension) family of homeodomain containing proteins. Meis1 binds to Hox and Pbx proteins to form complexes with distinct DNA-binding specificities. Like Hox and Pbx proteins, the overexpression of Meis1 in BHX-2 myeloid leukemias implies a role for this protein in oncogenesis. Two Meis related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and express in normal tissues as well as myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.
References
Product Information
Format Ascites
Control
  • K562 nuclear extract
Presentation mouse ascites IgG1 containing 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Detect Meis 1/2/3 with Anti-Meis 1/2/3 Antibody, clone 9.2.7 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB & IHC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry
Biological Information
Immunogen MBP-conjugated fusion protein corresponding to amino acids 60-390 of mouse Meis1
Clone clone 9.2.7
Host Mouse
Specificity Meis1, Meis2, Meis3 and splice variants
Isotype IgG1
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.
Gene Symbol
  • MEIS2
  • MGC2820
  • MRG1
  • HsT18361
Purification Method Ascites
UniProt Number
UniProt Summary SIZE: 477 amino acids; 51790 Da
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in various tissues. In hematopoietic tissues, the lymphoid organs express high levels of MEIS2. Also expressed in some regions of the brain, such as the putamen.
SIMILARITY: SwissProt: O14770 ## Belongs to the TALE/MEIS homeobox family. & Contains 1 homeobox DNA-binding domain.
Molecular Weight Mr ~45-66kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on nuclear extract from K562 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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