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Anti-NR2E3 (rabbit polyclonal)

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货号：AB2299

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, R, H WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB2299
Description Anti-NR2E3 Antibody
Alternate Names
  • Nuclear receptor subfamily 2 group E member 3
  • Retina-specific nuclear receptor
  • nuclear receptor subfamily 2
  • group E, member 3
  • photoreceptor-specific nuclear receptor
Background Information NR2E3 protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
Product Information
Format Purified
Control
  • Bovine Retina tissue lysate.
Presentation Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Applications
Application Anti-NR2E3 Antibody is an antibody against NR2E3 for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Full Length Recombinant Protein.
Epitope Full Length Protein
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Cat. # AB2299 recognizes NR2E3 protein.
Species Reactivity
  • Bovine
  • Rat
  • Human
Species Reactivity Note Bovine (Calf). May react with mouse, rat and human based on sequence homology. Reactivity with other species has not been determined.
Antibody Type Polyclonal Antibody
Gene Symbol
  • ESCS
  • MGC49976
  • PNR
  • RNR
  • RP37
  • rd7
Purification Method Purified by GST-depletion followed by Protein A
UniProt Number
UniProt Summary FUNCTION: Transcription factor that may have a role in the regulation of signaling pathways intrinsic to the photoreceptor cell function.

SUBCELLULAR LOCATION: Nucleus.

TISSUE SPECIFICITY: Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside.

DISEASE: Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS) [MIM:268100]. ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration. Ref.5 Ref.6 Ref.7 Ref.8

Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37) [MIM:611131]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant. Ref.9

SEQUENCE SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily.

Contains 1 nuclear receptor DNA-binding domain.
Molecular Weight ~44 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Western Blot:
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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