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Anti-MUC1/episialin, clone 214D4

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货号：05-652

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC, IHC M Purified Monoclonal Antibody
Description
Catalogue Number 05-652
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-MUC1/episialin Antibody, clone 214D4
Alternate Names
  • Breast carcinoma-associated antigen DF3
  • Carcinoma-associated mucin
  • Episialin
  • H23AG
  • PEMT
  • Peanut-reactive urinary mucin
  • PUM
  • Polymorphic epithelial mucin
  • PEM
  • Tumor-associated epithelial membrane antigen
  • EMA
  • Tumor-associated mucin
  • CD227
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-MUC1/episialin Antibody, clone 214D4 detects level of MUC1/episialin & has been published & validated for use in FC, IH.
Key Applications
  • Flow Cytometry
  • Immunohistochemistry
Biological Information
Immunogen Fusion protein, human b-gal-episialin/MUC1 repeat domain
Clone clone 214D4
Host Mouse
Specificity MUC1/episialin
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.
Gene Symbol
  • MUC1
  • MUC1/ZD
  • MUC-1/X
  • PEMT
  • MUC-1
  • Episialin
  • episialin
  • MUC-1/SEC
  • PUM
  • EMA
  • PEM
  • H23AG
  • MAM6
  • CD227
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P15941 # Isoform 7 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.
SIZE: 1255 amino acids; 122072 Da
SUBUNIT: The cleaved form (only the isoform 1) of MUC1 forms a tight heterodimer with the released C-terminal peptide (which is first secreted to be extracellular).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 5: Secreted. & Isoform 9: Secreted.
TISSUE SPECIFICITY: Expressed on ductal epithelial cells and on activated T-cells. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 expressed only in tumoral cells.
PTM: Highly glycosylated (N- and O-linked carbohydrates and sialic acid). In the 20 amino acid tandem repeat positions 5 (Ser), 6 (Thr), 14 (Thr), 15 (Ser) and 19 (Thr) are O-glycosylated (GalNAc). The average density of O-glycosylated sites within repeat peptides varies with cell differentiation from about 50% in lactation-associated MUC1 to over 90% in a variety of breast cancer cells. & Isoform 1 and isoform 7 undergoes transphosphorylation on serine and tyrosine residues.
SIMILARITY: SwissProt: P15941 ## Contains 1 SEA domain.
Molecular Weight none given
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunohistochemistry
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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