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Anti-PP2A, A-subunit, clone 4G7

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货号：05-657

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Xn WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-657
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-PP2A Antibody, A subunit, clone 4G7
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-PP2A Antibody, A subunit, clone 4G7 is an antibody against PP2A for use in WB.
Key Applications
  • Western Blotting
Application Notes Not recommended for IP
Biological Information
Immunogen Peptide corresponding to amino acids 6-19 (GDDSLYPIAVLIDE) of human Protein Phosphatase 2A, A subunit
Clone 4G7
Host Mouse
Specificity PP2A A subunit, α and β isoforms
Isotype IgG1
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Xenopus
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.
Gene Symbol
  • PPP2R1A
  • PR65A
  • MGC786
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P30153 # The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
SIZE: 589 amino acids; 65309 Da
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9.
DOMAIN: SwissProt: P30153 Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
SIMILARITY: Belongs to the phosphatase 2A regulatory subunit A family. & Contains 15 HEAT repeats.
Molecular Weight 65kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on RIPA lysates from NIH-3T3, HEK293, or HeLa cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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