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Anti-PXDN/VPO1 (rabbit polyclonal)

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货号：ABS1675

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, B WB, IH(P), IP Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS1675
Description Anti-PXDN/VPO1 Antibody
Alternate Names
  • Peroxidasin homolog
  • hsPxd01
  • Melanoma-associated antigen MG50
  • p53-responsive gene 2 protein
  • Vascular peroxidase 1
Background Information Peroxidasin homolog (EC 1.11.1.7; UniProt Q92626; also known as hsPxd01, Melanoma-associated antigen MG50, p53-responsive gene 2 protein, Vascular peroxidase 1) is encoded by the PXDN (also known as COPOA, KIAA0230, MG50, PRG2, VPO, VPO1) gene (Gene ID 7837) in human. Human peroxidasin 1 (hsPxd01) belong to the superfamily of heme peroxidases with important roles in innate immunity and hormone biosynthesis, members of which also include myeloperoxidase (MPO), eosinophil peroxidase (EPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO). Peroxidase 1 is a multidomain heme peroxidase that uses bromide as a cofactor in catalyzing the formation of sulfilimine bonds in collagen IV via release of hypohalous acids. Peroxidase 1 plays an essential role in tissue development and architecture by catalyzing sulfilimine bonds formation that confers critical structural reinforcement to collagen IV scaffolds. Human peroxidasin 1 is produced with a signal peptide sequence (a.a. 1-26), the remvoal of which yields the mature protein. In its N-terminal region, hsPxd01 contains four leucine-rich (LRR) repeats (a.a.87-180) flanked by two cysteine-rich domains, the LRRNT (a.a. 27-63) and LRRCT (a.a. 192-245), this is followed by four C2-type Ig-like domains, and a C-terminal von Willebrand factor type C domain (VWFC; a.a. 1413-1471) found in many secreted extracellular matrix proteins.
References
Product Information
Format Affinity Purified
Presentation Purified rabbit polyclonal antibody in 0.1 M Tris-glycine buffer containing 0.02% sodium azide.
Applications
Application This Anti-PXDN Antibody is validated for use in Western Blotting, Immunohistochemistry (Paraffin), Immunoprecipitation for the detection of PXDN.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
  • Immunoprecipitation
Application Notes Immunohistochemistry Analysis: A 1:400 diluttion from a representative lot detected VPO1 in mouse lung tissue sections (Courtesy of Guangjie Cheng, M.D., Emory University, GA, U.S.A.).
Immunoprecipitation Analysis: A representative lot immunoprecipitated all the radiolabelled VPO1 from the culture supernatant, but not from cell lysates, 20 hrs after an initial 20-min [32S]-Met pulse labeling of HEK293 cells stably expressing transfected VPO1 (Cheng, G., et al. (2011). Free Radic. Biol. Med. 51(7):1445-1453).
Western Blotting Analysis: A representative lots detected cellular VPO1 in total cell lysate and secreted VPO1 in concentrated culture medium following histone deacetylase inhibition by NaBu (Cat. No. 567430) treatment of HEK293 cells stably expressing exogenously transfected VPO1 (Cheng, G., et al. (2011). Free Radic. Biol. Med. 51(7):1445-1453).
Western Blotting Analysis: A representative lot detected VPO1 in human, mouse, and bovine sera samples, as well as a time-dependent cellular VPO1 upregulation in lysates from LPS- or TNF-alpha-stimulated HUVECs (Cheng, G., et al. (2011). Free Radic. Biol. Med. 51(7):1445-1453).
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to a LRRNT domain sequence of human PXDN/VPO1.
Epitope LRRNT domain.
Concentration Please refer to lot specific datasheet.
Host Rabbit
Specificity This polyclonal antibody was raised against an N-terminal region sequence present in both spliced isoforms of human VPO1/PXDN protein (UniProt Q92626), but not conserved in MPO, LPO, EPO and TPO (Cheng, G., et al. (2011). Free Radic. Biol. Med. 51(7):1445-1453).
Species Reactivity
  • Human
  • Mouse
  • Bovine
Species Reactivity Note Human, Mouse, Bovine.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PXDN
  • COPOA
  • KIAA0230
  • MG50
  • PRG2
  • VPO
  • VPO1
Purification Method Affinity purified.
UniProt Number
Molecular Weight >165 kDa observed. 162.4/165.3 kDa (human isoform 1 mature/pro-form), 77.50/80.33 kDa (human isoform 2 mature/pro-form), 162.4/165.1 kDa (mouse mature/pro-form) calculated. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting Analysis in human plasma.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected VPO1 in 10 µg of human plasma.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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