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Anti-ATRIP, Rabbit Polyclonal IgG

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货号：07-625

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-625
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-ATRIP Antibody
Overview Antibody recognizing ATR-Interacting Protein
References
Product Information
Format Purified
Presentation 70% storage buffer (0.05M Tris-glycine, 0.025M sodium phosphate, pH 7.4, 0.15M NaCl, 0.035% sodium azide) and 30% glycerol
Applications
Application Detect ATRIP with Anti-ATRIP Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB, ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen GST fusion protein corresponding to residues 1-181 of human ATR interacting protein (ATRIP)
Host Rabbit
Specificity ATRIP
Isotype IgG
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The product of this gene is an essential component of the DNA damage checkpoint, and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Symbol
  • ATRIP
  • MGC20625
  • DKFZp762J2115
  • FLJ12343
  • AGS1
  • MGC21482
  • MGC26740
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q8WXE1 # Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
SIZE: 791 amino acids; 85838 Da
SUBUNIT: Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA.
SUBCELLULAR LOCATION: Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage.
TISSUE SPECIFICITY: Ubiquitous.
DOMAIN:SwissProt: Q8WXE1 The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.
PTM: Phosphorylated by ATR.
SIMILARITY: Belongs to the ATRIP family.
Molecular Weight 85kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot on modified RIPA lysates from HEK293, HeLa and U20S cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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