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Anti-Na+ K+ ATPase a-2

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货号：07-674

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 07-674
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Na+K+ ATPase α-2 Antibody
References
Product Information
Format Serum
Applications
Application Anti-Na+K+ ATPase α-2 Antibody is an antibody against Na+K+ ATPase α-2 for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated, synthetic peptide (CKAGQENISVSKRDT) corresponding to amino acids 432-445 of human Na+K+ ATPase α-2, with an N-terminal cysteine added for conjugation purposes.
Host Rabbit
Specificity Na+/K+ ATPase α-2
Isotype IgG
Species Reactivity
  • Rat
Species Reactivity Note Predicted to crossreact with human, mouse, dog and monkey based on sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit.
Gene Symbol
  • ATP1A2
  • FHM2
  • MGC59864
  • KIAA0778
  • MHP2
  • Na
  • +K
Purification Method Antiserum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P50993 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
SIZE: 1020 amino acids; 112265 Da
SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P50993 # Defects in ATP1A2 are the cause of familial hemiplegic migraine 2 (FHM2) [MIM:602481]. Familial hemiplegic migraine is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. & Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age.
SIMILARITY: SwissProt: P50993 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.
Molecular Weight Mr 105kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot with rat brain microsomal preparation (catalog# 12-144)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 2 years at -20°C from date of shipment
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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