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Anti-DNMT1 100ul

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货号：07-688

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 07-688
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-DNMT1 Antibody
References
Product Information
Format Serum
Applications
Application Detect DNMT1 also known as DNA (cytosine-5)-methyltransferase 1 with Anti-DNMT1 Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen fusion protein corresponding to residues 913-1085 of human DNA methyltransferase 1 (DNMT1)
Host Rabbit
Specificity DNMT1
Isotype IgG
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.
Gene Symbol
  • DNMT1
  • Dnmt1
  • M.HsaI
  • DNA
  • FLJ16293
  • MCMT
  • AIM
  • DNMT
  • CXXC9
  • MGC104992
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P26358 # Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.
SIZE: 1616 amino acids; 183165 Da
SUBUNIT: Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
SIMILARITY: SwissProt: P26358 ## Belongs to the C5-methyltransferase family. & Contains 2 BAH domains. & Contains 1 CXXC-type zinc finger.
Molecular Weight 220kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot with RIPA lysates from HeLa nuclear extracts.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C from date of shipment
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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