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Rb X ASC [TMS1]

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货号：AB3607

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB3607
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-ASC Antibody
Alternate Names
  • TMS1
  • CARD5
  • Apoptosis-associated Speck-like Protein containing a CARD
Background Information Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
References
Product Information
Format Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Applications
Application This Anti-ASC Antibody is validated for use in WB for the detection of ASC.
Key Applications
  • Western Blotting
Application Notes Western blot: 1:500

HL60 whole cell lysate can be used as a positive control.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Peptide corresponding to aa 182-195 (RESQSYLVEDLERS) of human ASC.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Detects a 25 kDa band by western blot, corresponding to ASC/TMS1.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
Gene Symbol
  • PYCARD
  • TMS1
  • MGC10332
  • ASC
  • hASC
  • CARD5
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9ULZ3 # Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase 9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
SIZE: 195 amino acids; 21627 Da
SUBUNIT: Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PYDC1.
SUBCELLULAR LOCATION: Cytoplasm. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.
TISSUE SPECIFICITY: Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T- cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells.DOMAIN:SwissProt: Q9ULZ3 Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain.
PTM: Phosphorylated.
SIMILARITY: Contains 1 CARD domain. & Contains 1 DAPIN domain.
MISCELLANEOUS: In breast tumorigenesis, methylation-mediated silencing may affect genes and proteins that act as positive mediators of cell death.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 4°C for up to 6 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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