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Anti-c-Jun

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货号：06-225

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Av, H, M ICC, IP, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 06-225
Replaces 04-210
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-c-Jun Antibody
Alternate Names
  • Activator protein 1
  • AP1
  • p39
  • Proto-oncogene c-Jun
  • Transcription factor AP-1
  • V-jun avian sarcoma virus 17 oncogene homolog
Background Information c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced
signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.
References
Product Information
Format Serum
Control
  • Jurkat cell lysate
Presentation Whole rabbit antiserum containing 0.05% sodium azide
Applications
Application Detect c-Jun, also known as transcription factor AP-1, with Anti-c-Jun rabbit polyclonal antiserum, Cat. No. 06-225, that has been demonstrated to work in Immunocytochemistry, Immunoprecipitation, and Western blotting.
Key Applications
  • Immunocytochemistry
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen Trp E fusion-protein containing the DNA binding domain of avian c-Jun
Host Rabbit
Specificity c-Jun
Isotype IgG
Species Reactivity
  • Avian
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Gene Symbol
  • JUN
Purification Method Antiserum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
SIZE: 331 amino acids; 35676 Da
SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.
SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain.
Molecular Weight 35-39 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on RIPA lysates from human A431 cells or in Jurkat cell lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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