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Anti-Collagen IV 7S Domain (Mouse Monoclonal)

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货号：MAB3326

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ELISA, WB, IH(P) M Purified Monoclonal Antibody
Description
Catalogue Number MAB3326
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Collagen Type IV Antibody, 7S Domain, clone IV-4H12
References
Product Information
Format Purified
Control
  • POSITIVE CONTROL: human placental tissues.
Presentation Liquid in 0.1 M sodium phosphate buffer, pH 7.0, containing 2% protease-free bovine serum albumin.
Applications
Application This Anti-Collagen Type IV Antibody, 7S Domain, clone IV-4H12 is validated for use in ELISA, WB, IH(P) for the detection of Collagen Type IV.
Key Applications
  • ELISA
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Western blot. Detects human type IV collagen from human placental tissues at 2 μg/mL, giving a band at approximately 92 kDa. Optimal working dilutions must be determined by end user.
Biological Information
Epitope 7S Domain
Clone IV-4H12
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Specifically reactive with human Type IV Collagen.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Gene Symbol
  • COL4A1
  • Arresten
  • arresten
Non-Reactive Species
  • Rat
UniProt Number
UniProt Summary FUNCTION: SwissProt: P02462 # Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits endothelial cell proliferation and angiogenesis. Inhibits angiogenesis potentially via mechanisms involving cell surface proteoglycans and the alpha and beta integrins of endothelial cells.
SIZE: 1669 amino acids; 160615 Da
SUBUNIT: There are six type IV collagen isoforms, alpha 1(IV)- alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
TISSUE SPECIFICITY: Highly expressed in placenta.
DOMAIN: SwissProt: P02462 Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G- X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
PTM: Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates. & Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. & The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.
DISEASE: SwissProt: P02462 # Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant. & Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.
SIMILARITY: Belongs to the type IV collagen family. & Contains 2 COL4C (collagen IV C-terminal) domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Manufactured by Daiichi Fine Chemical Co., Ltd
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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