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Anti-STAT2

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货号：06-502

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M EMSA, IP, WB, ICC Rb Purified Polyclonal Antibody
Description
Catalogue Number 06-502
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-STAT2 Antibody, CT
References
Product Information
Format Purified
Presentation 0.07 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide and 30% glycerol.
Applications
Application Anti-STAT2 Antibody, CT is a Rabbit Polyclonal Antibody for detection of STAT2 also known as Signal Transducer & Activator of Transcription 2 & has been tested in EMSA, IP, WB, ICC.
Key Applications
  • Electrophoretic Mobility Shift Assay
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen GST fusion protein containing amino acids 671-806 of human STAT2
Host Rabbit
Specificity STAT2
Isotype IgG
Species Reactivity
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
Gene Symbol
  • STAT2
  • ISGF-3
  • P113
  • p113
  • STAT113
  • MGC59816
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P52630 # Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
SIZE: 851 amino acids; 97916 Da
SUBUNIT: Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
PTM: Tyrosine phosphorylated in response to IFN-alpha.
SIMILARITY: SwissProt: P52630 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
Molecular Weight 113kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Immunoblot Analysis: 0.5-2 μg/ml of this antibody detected STAT2 (113kDa) in Jurkat cell lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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