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PP1A 10ug

市场价：: 0.00

促销价：: ¥0.00

货号：14-595

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

Description
Catalogue Number	14-595
Brand Family	Upstate
Trade Name	Upstate
Description	PP1α Protein, 10 µg
Overview	recombinant, full length, human PP1α

References

Product Information

Applications
Application	Recombinant, full length, human PP1α, for use in Phosphatase Assays.
Key Applications	Phosphatase Assay

Biological Information
Source	expressed in E. coli cells
Specific Activity	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
Entrez Gene Number	NM_001008709.1 NM_002708.3 NM_206873.1
Entrez Gene Summary	The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Symbol	PPP1CA PP-1A MGC15877 MGC1674 PPP1A
Protein Target	PP1α
Purification Method	Heparin agarose followed by Q agarose
Target Sub-Family	Ser/Thr phosphatase
UniProt Number	P62136
UniProt Summary	FUNCTION: SwissProt: P62136 # Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity). SIZE: 330 amino acids; 37512 Da SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R9A and PPP1R9B (By similarity). Interacts with PPP1R7. SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: SwissProt: P62136 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
Molecular Weight	37.6kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	routinely evaluated by dephosphorylation of 100μM DiFMUP
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	6 months at -20°C from date of shipment

Packaging Information
Material Size	10 µg
Material Package	Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.

Transport Information

Supplemental Information

Specifications

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