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Anti-FFAR3/GPR41, clone 16F4.1 (mouse monoclonal)

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货号：MABN898

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IH(P) M Purified Monoclonal Antibody
Description
Catalogue Number MABN898
Description Anti-FFAR3/GPR41 Antibody, clone 16F4.1
Alternate Names
  • Free fatty acid receptor 3
  • G-protein coupled receptor 41
Background Information Free fatty acid receptor 3 (UniProt O14843; also known as G-protein coupled receptor 41) is encoded by the FFAR3 (also known as GPR41) gene (Gene ID 2865) in human. Free fatty acids (FFAs) act as both energy sources and signaling molecules via G-protein-coupled receptors (GPCRs) called FFARs (FFA receptors). FFAs are categorized by the length of their carbon chains into short-chain FAs (SCFAs; less than 6 carbons), medium-chain FAs (MCFAs; 6–12 carbons), and long-chain FAs (LCFAs; more than 12 carbons). MCFAs and LCFAs activate FFAR1 and FFAR4, whereas SCFAs activate FFAR3 and FFAR2. FFAR3 is an SCFA receptor that can be activated by propionate (C3), butyrate (C4), and valerate (C5). FFAR3 mediates PYY and GLP-1 secretion from endocrine and sympathetic outflow-dependent heart rate regulation and energy expenditure, while β-Hydroxybutyrate, a ketone body produced in the liver during starvation, decreases sympathetic outflow by antagonizing FFAR3. FFAR3 is shown to couple Gαi/o pathway signaling upon activation by propionate binding in primary murine pancreatic beta cells, resulting in an inhibition of glucose-dependent insulin secretion. FFAR3 is a 7-transmembrane (a.a. 20-40, 48-68, 89-111, 133-153, 179-199, 223-243, 259-279) GPCR, having a short N-terminal extracellular portion (a.a. 1-19) and a long C-terminal cytomplasmic tail (a.a. 280-346).
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-FFAR3 Antibody, clone 16F4.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of GPR41.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected FFAR3/GPR41 in human breast cancer tissue, as well as in normal liver, pancreas, and small intestine tissue sections.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to a C-terminal cytoplasmic domain sequence of human FFAR3/GPR41.
Epitope C-terminal cytoplasmic domain.
Clone 16F4.1
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity Clone 16F4.1 targets an epitope in the C-terminal cytoplasmic domain of human FFAR3/GPR41.
Isotype IgG1κ
Species Reactivity
  • Human
Species Reactivity Note Human.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • FFAR3
  • GPR41
Purification Method Protein G purified.
UniProt Number
Molecular Weight ~41 kDa observed. 38.65 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in human adipose tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected FFAR3/GPR41 in 10 µg of human adipose tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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