Anti-PARIS/ZNF746, clone 10H11.3 (mouse monoclonal) - 炼石商城

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Anti-PARIS/ZNF746, clone 10H11.3 (mouse monoclonal)

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货号：MABN239

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, IH(P)	M	Culture Supernatant	Monoclonal Antibody

Description
Catalogue Number	MABN239
Description	Anti-PARIS/ZNF746 Antibody, clone 10H11.3
Alternate Names	Zinc finger protein 746 PARIS Parkin-interacting substrate
Background Information	Zinc finger protein 746 (UniProt Q6NUN9; also known as PARIS, Parkin-interacting substrate) is encoded by the ZNF746 (also known as PARIS) gene (Gene ID 155061) in human. ZNF746/PARIS is a krueppel C2H2-type zinc-finger family transcription regulator that targets the insulin response sequences in the PGC-1α promoter and represses the expression of the transcriptional coactivator PGC-1α. ZNF746/PARIS contains a Kruppel-associated box (CRAB) in its N-terminal region (a.a. 96-167) and four C2H2-type zinc fingers in its C-terminal region (a.a. 453-478, 510-522, 538-560, 566-588). ZNF746/PARIS intracellular level is normally regulated by proteasomal degradation via E3 ubiquitin ligase parkin-mediated ubiquitination. Uncontrolled ZNF746/PARIS level results in excess activation of PGC-1α target gene NRF-1. Conditional knockout of parkin in adult animals leads to progressive loss of dopamine (DA) neurons in a ZNF746/PARIS-dependent manner. Similarly, ZNF746/PARIS overexpression leads to selective loss of DA neurons in the substantia nigra, which is reversed by either parkin or PGC-1α coexpression. ZNF746 is also reported to play a positive role in promoting H460 non-small cell lung cancer (NSCLC) cell invasion and epithelial to mesenchymal transition (EMT). ZNF746 silencing suppresses H460 invasion as a result of downregulated MMP1/2/9 expression and upregulated E-cadherin and β-catenin, leading to attenuated expression of key EMT transcriptional factors.

References

Product Information
Format	Culture Supernatant
Presentation	Mouse monoclonal IgG1κ hybridoma culture supernatant without preservatives.

Applications
Application	This Anti-PARISAntibody, clone 10H11.3 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of ZNF746.
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PARIS/ZNF746 in mouse cerebellum, as well as human cerebellum, kidney, and testis tissue sections

Biological Information
Immunogen	GST-tagged recombinant human PARIS/ZNF746 C-terminal fragment.
Epitope	C-terminal region.
Clone	10H11.3
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone 10H11.3 targets a C-terminal region present in all three spliced isoforms of human PARIS/ZNF746 reported by UniProt (Q6NUN9).
Isotype	IgG1κ
Species Reactivity	Human Mouse
Species Reactivity Note	Human, Mouse.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_689770
Gene Symbol	ZNF746 PARIS
Purification Method	Unpurified.
UniProt Number	Q6NUN9
Molecular Weight	69.14 kDa (isoform 1), 69.21 kDa (isoform 2), 48.45 kDa (isoform 3) calculated. Uncharacterized band(s) may appear in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting of PARIS/ZNF746 recombinant protein. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected 10 µg of human PARIS/ZNF746 C-terminal fragment GST fusion.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

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