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Rb X Vasopressin V2 Receptor

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货号：AB9500

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB9500
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Vasopressin V2 Receptor Antibody
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
Applications
Application This Anti-Vasopressin V2 Receptor Antibody is validated for use in IH(P) for the detection of Vasopressin V2 Receptor.
Key Applications
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry on paraffin embedded tissue sections.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide from the 3rd cytoplasmic domain of human Vasopressin V2 Receptor.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes Vasopressin V2 Receptor.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
Gene Symbol
  • AVPR2
  • DI1
  • V2R
  • MGC126533
  • DIR
  • DIR3
  • ADHR
  • NDI
  • MGC138386
UniProt Number
UniProt Summary FUNCTION: SwissProt: P30518 # Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
SIZE: 371 amino acids; 40279 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Kidney.
DISEASE: SwissProt: P30518 # Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. & Defects in AVPR2 are a cause of X-linked nephrogenic diabetes insipidus, type I (NDI) [MIM:304800]. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria) and fail to concentrate urine in response to vasopressin. Most cases of NDI appear to have an X-linked recessive pattern of inheritance.
SIMILARITY: SwissProt: P30518 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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