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Anti-phospho-Cofilin 2 (Ser3)

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号:07-326

牌:Millipore 密理博

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Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ch, H, M WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-326
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-phospho-Cofilin 2 (Ser3) Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-phospho-Cofilin 2 (Ser3) Antibody detects level of phospho-Cofilin 2 (Ser3) & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen peptide corresponding to amino acids 1-10 (MA[pS]GVTVNDE-C) of human phospho-Cofilin 2
Host Rabbit
Specificity phospho-Cofilin 2
Isotype IgG
Species Reactivity
  • Chicken
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190]; Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]).[supplied by OMIM]
Gene Symbol
  • CFL2
  • NEM7
  • Cofilin-2
Modifications
  • Phosphorylation
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9Y281 # Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
SIZE: 166 amino acids; 18737 Da
SUBCELLULAR LOCATION: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (By similarity).
TISSUE SPECIFICITY: Isoform CFL2b is expressed predominantly in skeletal muscle and heart, while isoform CFL2a is expressed in various tissues.
PTM: The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
DISEASE: SwissProt: Q9Y281 # Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) [MIM:610687]. Nemaline myopathy (NEM) is a form of congenital myopathy characterized by abnormal thread- or rod-like structures in muscle fibers on histologic examination. The clinical phenotype is highly variable, with differing age at onset and severity.
SIMILARITY: SwissProt: Q9Y281 ## Belongs to the actin-binding proteins ADF family. & Contains 1 ADF-H domain.
Molecular Weight 21kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on RIPA lysates from L6 cells, treated with LIM Kinase
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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