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Anti-Fce RIa

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货号：05-468

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R FC, IP M Purified Monoclonal Antibody
Description
Catalogue Number 05-468
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-FcεRI α subunit Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, 0.15M NaCl, 0.05% sodium azide prior to the addition of glycerol to 30%
Applications
Application Anti-FcεRI α subunit Antibody is an antibody against FcεRI α subunit for use in FC & IP.
Key Applications
  • Flow Cytometry
  • Immunoprecipitation
Application Notes Western blot is not recommended
Biological Information
Immunogen Whole rat basophilic leukemia cells, positive for the rat high-affinity receptor recognizing immunoglobulin E (FcεRI).
Host Mouse
Specificity FcεRIα
Isotype IgG1κ
Species Reactivity
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM]
Gene Symbol
  • FCER1A
  • FcERI
  • FCE1A
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P12319 # Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
SIZE: 257 amino acids; 29596 Da
SUBUNIT: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P12319 ## Contains 2 Ig-like (immunoglobulin-like) domains.
Molecular Weight 45-55kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoprecipitation of rat FcεRIα from biotinylated rat basophilic leukemia cell lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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