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Mouse Anti-cdk1/p34cdc2 Kinase Monoclonal Antibody

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货号：MAB8878

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ch, H, M, R, Xn IF, IP, Enzyme Assays, WB, IH(P) M Purified Monoclonal Antibody
Description
Catalogue Number MAB8878
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Cdk1 Antibody, clone A17.1.1
Alternate Names
  • p34cdc2
  • CDC2
References
Product Information
Format Purified
Control
  • POSITIVE CONTROL:

    HeLa or NIH3T3 cells. Germinal center in a tonsil or reactive lymph node. Cellular localization is predominantly nuclear, with some cytoplasmic staining.
Presentation Purified immunoglobulin. 0.2 mg/mL in 10 mM PBS, pH 7.4, containing 0.2% BSA and 0.09% Sodium Azide.
Applications
Application Anti-Cdk1 Antibody, clone A17.1.1 is a Mouse Monoclonal Antibody for detection of Cdk1 also known as p34cdc2, CDC2 & has been validated in IF, IP, EA, WB, IHC(P).
Key Applications
  • Immunofluorescence
  • Immunoprecipitation
  • Enzyme Assays
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Frozen Sections

Immunofluorescence

Immunoprecipitation: (Native/denatured, Protein A; 2μg/mg protein lysate)

Immunohistology (Formalin, 2-4μg/mL for 30 min at RT)

Paraffin Sections (staining requires antigen retrieval).

Western Blotting

Kinase Assay

Optimal working dilutions must be determined by the end user.

p34cdc2, a serine/threonine kinase, is activated by cyclins, presumably by dephosphorylation of tyrosine residues. MAB8878 inhibits the activation of p34cdc2 kinase by cyclins and precipitates an active kinase.
Biological Information
Immunogen Raised against Xenopus p34cdc2.
Clone A17.1.1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Recognizes a 34 kDa protein cdk1, identified as cdk1/p34cdc2 protein kinase (a catalytic subunit of Maturation Promoting Factor). Its epitope maps near the C-terminus of protein and its core is thought to be LGTPNNEV. It shows no cross-reaction with cdk2/p32 and other cyclin dependent kinases (cdks).
Isotype IgG2a
Species Reactivity
  • Chicken
  • Human
  • Mouse
  • Rat
  • Xenopus
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Gene Symbol
  • CDC2
  • CDK1
  • DKFZp686L20222
  • MGC111195
  • CDC28A
  • EC 2.7.11.22
  • EC 2.7.11.23
UniProt Number
UniProt Summary FUNCTION: SwissProt: P06493 # Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
SIZE: 297 amino acids; 34095 Da
SUBUNIT: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with DLG7. Isoform 2 is unable to complex with cyclin B1 and also fails to bind to the CDK inhibitor p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase.
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: SwissProt: P06493 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2° to 8°C in undiluted aliquots for up to 12 months from date of receipt.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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