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Anti-Tau (4-repeat isoform RD4), clone 7D12.1 (mouse monoclonal)

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货号：MABN1185

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R WB, IH(P) M Purified Monoclonal Antibody
Description
Catalogue Number MABN1185
Description Anti-Tau (4-repeat isoform RD4) Antibody, clone 7D12.1
Alternate Names
  • Microtubule-associated protein tau, 4-repeat isoforms
  • Neurofibrillary tangle protein, 4-repeat isoforms
  • Paired helical filament-tau, 4-repeat isoforms
  • PHF-tau
  • PNS-tau
  • Tau-D
  • Tau-E
  • Tau-F
  • Tau-G
Background Information Microtubule-associated protein tau (UniProt P10636; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as MAPTL, MTBT1, TAU) gene (Gene ID 4137) in human. Extracellular plaque deposits composed of amyloid-β and intracellular neurofibrillary tangles (NFTs) composed of truncated and hyperphosphorylated tau are two neuropathological hallmarks of Alzheimer's disease (AD). Tau pathology (tauopathy) can cause toxicity when the brain is devoid of amyloid plaques, and tangle pathology correlates better with clinical dementia than amyloid pathology. Abnormal processing of tau by hyperphosphorylation and proteolytic truncation contribute to the toxicity of tau. Tau also undergoes other types of posttranslational modifications, including glycosylation, ubiquitination, glycation, polyamination, nitration, and lysine methylation, which are believed to be important for its non-pathological functions, including polymerization and stabilization of microtubules. Alternative splicings result in multiple Tau isoforms, including five human Tau spliced isoforms with four C-terminal microtubule-binding repeats/domains (RD4) and four spliced isoforms that contain only three microtubule-binding domains (RD3) due to the absence of exon 10-conding sequence. Isoform-specific antibodies are useful tools for analyzing tau isoforms expression and distribution as well as pathological changes in the human brain.
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Tau Antibody, clone 7D12.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Tau (4-repeat isoform RD4).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected Tau 4-repeat isoforms in Alzheimer's diseased (AD) human brain, as well as human kidney and non-AD brain tissue sections.
Biological Information
Immunogen KLH-conjugated synthetic peptide (VQIINKKLDLSNVQSKC) corresponding to a junction-flanking sequence coded by adjacent exons 9 & 10 of Tau. The immunizing sequence is identical in human, rat, mouse and bovine.
Epitope Junction-flanking region coded by adjacent exons 9 & 10.
Clone 7D12.1
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity Clone 7D12.1 targets an epitope sequence present in Tau spliced isoforms with four C-terminal microtubule-binding repeats/domains (RD4), including human isoforms PNS-tau, Tau-D, Tau-E, Tau-F, and Tau-G, but not Tau spliced isoforms that contain only three microtubule-binding domains (RD3) due to the absence of exon 10-conding sequence (human isoforms Fetal-tau, Tau-A, Tau-B, and Tau-C).
Isotype IgG1κ
Species Reactivity
  • Human
  • Rat
Species Reactivity Note Human, Rat. Predicted to react with Bovine, Mouse based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • MAPT
  • MAPTL
  • MTBT1
  • TAU
Purification Method Protein G purified.
UniProt Number
Molecular Weight ~45-58 kDa observed. 78,80 kDa (human isoform 1; PNS-tau), 39.88 kDa (human isoform 6; Tau-D), 42.84 kDa (human isoform 7; Tau-E), 45.72 kDa (human isoform 8; Tau-F), 80.81 kDa (human isoform 9; Tau-G) calculated (Met1 removed).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in rat brain tissue cytosol lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected Tau 4-repeat isoforms in 10 µg of rat brain tissue cytosol lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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