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Anti-FMC-7 B-Cell Lymphocyte Marker, cln FMC-7, FITC

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货号：MAB1217F

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC M FITC Monoclonal Antibody
Description
Catalogue Number MAB1217F
Replaces CBL1416F
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-FMC-7 B-Cell Lymphocyte Marker Antibody, clone FMC-7, FITC conjugated
Overview BIOCHEMISTRY: p I = 7.4
Background Information B cells are lymphocytes that play a large role in the humoral immune response as opposed to the cell-mediated immune response that is governed by T cells. The principal function of B cells is to make antibodies against soluble antigens. B cells are an essential component of the adaptive immune system. FMC-7 B-Cell Lymphocyte Marker is a 105 kDa B cell restricted antigen which is expressed on about 50% of adult human peripheral blood B cells. Upon in vivo B cell activation FMC7 expression initially increases. B cells involved in antibody secretion have lost the FMC7 determinant. The monoclonal antibody FMC7 delineates a subpopulation of B lymphocytes in normal blood. Expression of the antigen recognized by FMC7 appears to be maturation-linked, and it serves to distinguish different types of B cell leukemia.
References
Product Information
Format FITC
Control
  • Human peripheral blood lymphocytes, HRIK and Raji cell lines
Presentation The antibody is supplied in 1.0 ml 0.1M Tris-HCl, 0.5M NaCl, 10mM glycine, pH 8.0, containing 0.2% bovine serum albumin and 0.1% sodium azide. The characteristics of each lot are tested by electrophoresis and flow cytometry.
Applications
Application This Anti-FMC-7 B-Cell Lymphocyte Marker Antibody, clone FMC-7, FITC conjugated is validated for use in Flow Cytometry (FC) for the detection of FMC-7 B-Cell Lymphocyte Marker.
Key Applications
  • Flow Cytometry
Application Notes This antibody can be used for the differentiation of PLL from B-CLL. It is also useful in confirmation of the diagnosis of other disorders such as HCL, HCL-V and SLVL. Useful for the detection of residual disease in patients undergoing treatment for these disorders.


SUGGESTED USAGE:

Flow cytometry - use 10 μl direct from the vial per 100 μl of whole blood, or 1 x 10E6 peripheral blood mononuclear cells (PBMC) in 100 μl buffer.
Biological Information
Immunogen The human B-lymphoblastoid cell line, HRIK.
Clone FMC-7
Host Mouse
Specificity The FMC-7 antibody was not clustered at the 5th Leucocyte Typing Workshop held in Boston USA 1993. This antibody detects a glycoprotein of 105kD found on circulating B-lymphocytes (Brooks et al., 1981). Studies on normal lymphocytes, leukaemic cells and cell lines indicate that FMC-7 is a marker for a limited segment of the B cell maturation pathway (Catovsky et al., 1981; Zola et al., 1984). This glycoprotein is expressed in varying degrees on normal circulating B-cells, chronic B-cell leukaemia (B-CLL), prolymphocytic leukaemia (PLL) and other B cell neoplasias (Zola et al., 1984, 1987; Bloem et al., 1988; Melo et al., 1988; Ferro & Zola, 1990; Mulligan, 1990; Zola et al., 1991; Burthem & Cawley, 1994; Huh et al., 1994). It labels the same population as CD22 antibodies but reacts with a different antigen (Zola et al. 1987).

Cell reactivity:1

Stains peripheral blood B lymphocytes and tonsil B lymphocytes. No reaction with granulocytes, monocytes, platelets, erythrocytes, T lymphocytes or null cells. Reacts with HRIK and Raji cell lines.

Clinical9,12,13 Expression

B cell prolymphocytic leukemia (B-PLL) Strongly positive

Hairy cell leukemia (HCL) Strongly positive

Hairy cell leukaemia variant (HCL-V) Strongly positive

Splenic lymphoma with villous lymphocytes (SLVL) Positive

B cell chronic lymphocytic leukaemia (B-CLL) Negative to weakly positive
Isotype IgM
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Gene Symbol
  • FMC-7
  • FMC7
Molecular Weight 105 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at 2 to 8°C, for up to 6 months. DO NOT FREEZE. Protect from light.

WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water.
Packaging Information
Material Size 100 assays
Transport Information
Supplemental Information
Specifications

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