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Anti-FRS2/SNT-1 (mouse monoclonal IgG)

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货号：05-502

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R IP, WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-502
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-FRS2/SNT-1 Antibody
References
Product Information
Format Purified
Presentation 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol
Applications
Application Detect FRS2/SNT-1 using this Anti-FRS2/SNT-1 Antibody validated for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen Peptide corresponding to residues 283-297 of human FRS2/SNT-1
Host Mouse
Specificity FRS2/SNT-1 in unstimulated cells and phosphorylated FRS2/SNT-1 in NGF-stimulated cells
Isotype IgG
Species Reactivity
  • Human
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • FRS2
  • SNT1
  • FRS2A
  • SNT-1
  • SNT
  • FRS2alpha
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q8WU20 # Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
SIZE: 512 amino acids; 57528 Da
SUBUNIT: Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine- phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.
SUBCELLULAR LOCATION: Intracytoplasmic membrane. Note=Cytoplasmic, membrane-bound.
TISSUE SPECIFICITY: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
PTM: Phosphorylated on tyrosine residues upon stimulation by NGF. & Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).
SIMILARITY: SwissProt: Q8WU20 ## Contains 1 IRS-type PTB domain.
Molecular Weight non-phosphorylated (68kDa) and phosphorylated (83kDa)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoprecipitating FRS2/SNT-1 from NGF-stimulated and unstimulated rat PC-12 RIPA cell lysates, subsequently immunoblotted with the same antibody.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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