Anti-Transient Rcpt Pot Channel 7 (Rb Polyclonal) - 炼石商城

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Anti-Transient Rcpt Pot Channel 7 (Rb Polyclonal)

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货号：AB15562-200UL

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M, R	ICC, WB	Rb	Purified	Polyclonal Antibody

Description
Catalogue Number	AB15562-200UL
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Transient Receptor Potential Channel 7 Antibody
Alternate Names	TRPM7 LTRPC7 Channel-kinase 1

References

Product Information
Format	Purified
Control	Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
Presentation	Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 200 uL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).

Applications
Application	This Anti-Transient Receptor Potential Channel 7 Antibody is validated for use in IC, WB for the detection of Transient Receptor Potential Channel 7.
Key Applications	Immunocytochemistry Western Blotting
Application Notes	Western blot: 1:200-1:500 using ECL on mouse brain lysate and GH3 cell line (rat pituitary tumor) lysate. Immunocytochemistry: 1:200 using GH3 cell line (rat pituitary tumor). Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	Purified peptide from the C-terminus of human TRPM7 (Accession number Q96QT4).
Host	Rabbit
Specificity	Recognizes Transient Receptor Potential Channel 7 (TRPM7, LTRPC7, Channel-kinase 1).
Species Reactivity	Mouse Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_017672.3
Entrez Gene Summary	TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]
Gene Symbol	TRPM7 TRP-PLIK LTRPC7 LTrpC7 FLJ20117 CHAK FLJ25718 CHAK1 EC 2.7.11.1
Purification Method	ImmunoAffinity Purified
UniProt Number	Q96QT4
UniProt Summary	FUNCTION: SwissProt: Q96QT4 # Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). COFACTOR: Binds 1 zinc ion per subunit (By similarity). SIZE: 1865 amino acids; 212697 Da SUBUNIT: Homodimer (By similarity). Forms heterodimers with TRPM6. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). PTM: Autophosphorylated (By similarity). DISEASE: SwissProt: Q96QT4 # Defects in TRPM7 influences susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 [MIM:105500]; also called amyotrophic lateral sclerosis- parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodengenerative disorder with unusually high incidence among the Chamorro people of the Western Pacific Islands of Guam. Both amyotrophic lateral sclerosis and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual. SIMILARITY: SwissProt: Q96QT4 ## In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily. & Contains 1 alpha-type protein kinase domain.

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Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Packaging Information
Material Size	200 µL

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