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Anti-Nucleolin, clone 3G4B2

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货号：05-565

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ca, H, Mk IP, WB, ICC M Culture Supernatant Monoclonal Antibody
Description
Catalogue Number 05-565
Replaces MABE466
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Nucleolin Antibody, clone 3G4B2
Background Information Nucleolin, also known as C23, is the major nucleolar protein of exponentially growing eukaryotic cells. It is a ubiquitous conserved multi-domain phosphoprotein found in all vertebrate species. Nucleolin contains a specific bipartite nuclear localization signal sequence and three different structural domains. Nucleolin is a multifunctional protein involved in most steps of ribosome biogenesis. Nucleolin has been implicated in chromatin structure, rDNA transcription, rRNA maturation, ribosome assembly, cytokinesis, nucleogenesis, cell proliferation and growth, and
nucleo-cytoplasmic transport. Nucleolin also exhibits autodegradation, DNA and RNA helicase activities, and DNA-dependent ATPase activity. Nucleolin activities may be regulated by proteolysis, methylation, ADPribosylation, and phosphorylation by several kinases, including casein kinase II (CK2), p34cdc2, and protein kinase C-ζ.
References
Product Information
Format Culture Supernatant
Control
  • HeLa nuclear extract
Presentation mouse culture supernatant containing 0.05% sodium azide prior to the addition of glycerol to 30%
Applications
Application Anti-Nucleolin Antibody, clone 3G4B2 is a high quality Mouse Monoclonal Antibody for the detection of Nucleolin & has been validated in IP, WB, ICC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen Nuclear matrix extract from MDCK cells
Clone clone 3G4B2
Host Mouse
Specificity nucleolin
Isotype IgG
Species Reactivity
  • Canine
  • Human
  • Monkey
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
Gene Symbol
  • NCL
  • FLJ45706
  • nucleolin
  • C23
  • Nucleolin
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P19338 # Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation.
SIZE: 710 amino acids; 76614 Da
SUBUNIT: Interacts with APTX and NSUN2. Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a complex which is at least composed of HTATSF1/Tat- SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin.
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: SwissProt: P19338 ## Contains 4 RRM (RNA recognition motif) domains.
Molecular Weight 100kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on HeLa nuclear extract
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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