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Anti-Caspase-3 (rabbit polyclonal IgG)

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货号：06-735

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 06-735
Replaces 04-1090; 04-439
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Caspase 3 Antibody
Background Information Caspase-3/Yama/Apopain, also known as proICE and CPP32, is a member of the ICE-like protease family. Caspase-3 is expressed as a 32 kDa precursor, which is proteolytically cleaved to yield an active form comprised of 17kDa and 12kDa subunits, respectively. The active enzyme appears to play an important role in the regulation or execution of apoptosis. One of its target substrates is the enzyme poly (ADP-ribose) polymerase (PARP) which is involved in DNA repair and maintenance of genome integrity.
References
Product Information
Format Purified
Control
  • Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Presentation Protein A purified IgG in of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl,and 0.05% sodium azide.
Applications
Application This Anti-Caspase 3 Antibody is validated for use in WB for the detection of Caspase 3.
Key Applications
  • Western Blotting
Application Notes Suggested dilutions:
Western Blot: 1 μg/mL
Biological Information
Immunogen Human full-length Caspase 3 fusion protein containing a histidine-6 tag
Host Rabbit
Specificity Recognizes full-length Caspase 3 (Yama/Apopain) and proteolytic fragments.
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Gene Symbol
  • CASP3
  • CPP-32
  • Apopain
  • Yama
  • CPP32B
  • apopain
  • procaspase3
  • CASP-3
  • SCA-1
  • CPP32
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: P42574 # Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
SIZE: 277 amino acids; 31608 Da
SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
SIMILARITY: SwissProt: P42574 ## Belongs to the peptidase C14 family.
Molecular Weight 32 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on RIPA lysates from non-stimulated human A431 cells, mouse 3T3/A31 or rat PC12 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 2 years at 2-8°C from date of shipment. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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