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Anti-p38/SAPK2, clone 2F11 (mouse monoclonal)

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货号：MABS1754

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB M Purified Monoclonal Antibody
Description
Catalogue Number MABS1754
Replaces 05-454
Description Anti-p38/SAPK2 Antibody, clone 2F11
Alternate Names
  • Mitogen-activated protein kinase 14
  • CRK1
  • MAP kinase 14
  • MAP kinase p38 alpha
  • MAPK 14
  • MAX-interacting protein 2
  • Mitogen-activated protein kinase p38 alpha
  • p38a
  • p38alpha
  • p38MAPK
  • SAPK2a
  • Stress-activated protein kinase 2a
Background Information Mitogen-activated protein kinase 14 (EC 2.7.11.24; UniProt P47811; also known as CRK1, MAP kinase 14, MAP kinase p38 alpha, MAPK 14, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, p38a, p38alpha, p38MAPK, SAPK2a, Stress-activated protein kinase 2a) is encoded by the Mapk14 (also known as Crk1, Csbp1, Csbp2, Mxi2) gene (Gene ID 26416) in murine species. p38 mitogen-activated protein kinases (MAPKs) constitute a group of stress-activated serine/threonine-specific kinases (SAPKs), including p38α (MAPK14/SAPK2A), p38β (MAPK11/SAPK2B), p38γ (ERK6/MAPK12/SAPK3), and p38δ (MAPK13/SAPK4), that mediate cellular signal transduction and play a vital role in numerous biological processes. p38α and p38β are ubiquitously expressed, while p38γ and p38δ are differentially expressed depending on tissue type. Sequence comparisons show approximately 60% identity within the p38 group. but only 40-45% to the other three MAP kinase family groups, extracellular signal-regulated kinases (ERKs), c-jun N-terminal or stress-activated protein kinases (JNK/SAPK), and ERK/big MAP kinase 1 (BMK1). All four p38 kinases contain a conserved Thr-Gly-Tyr (TGY) dual phosphorylation motif and are activated by dual kinases called MAP kinase kinases (MKKs).
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-p38 Antibody, clone 2F11 is validated for use in Western Blotting for the detection of SAPK2.
Key Applications
  • Western Blotting
Application Notes Western Blotting Analysis: A 1:500 dilution from a representative lot detected p38/SAPK2 in 10 µg of mouse (C2C12, NIH/3T3, RAW264), rat (L6, PC12), and human (HEK293, HeLa, HepG2, HUVEC, Jurkat) cell lysates, and in 10 µg of mouse brain homogenate.
Western Blotting Analysis: Representative lots detected p38 in human A549 epidermoid carcinoma cell and WI38-VA13 fibroblast lysates (Song, J.Y., et al. (2010). J. Biol. Chem. 285(12):9067-9076; Song, J.Y., et al. (2009). Cancer Lett. 283(2):135-142).
Western Blotting Analysis: A representative lot detected p38 in mouse embryonic stem cell lysate (Wu, X., et al. (2007). Dev. Dyn. 236(10):2767-2778).
Biological Information
Immunogen Full-length murine p38/SAPK2a GST fusion protein.
Clone 2F11
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity Clone 2F11 recognizes both p38alpha/SAPK2a and p38beta/SAPK2b.
Isotype IgG1κ
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Human, Mouse, Rat.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Mapk14
  • Crk1
  • Csbp1
  • Csbp2
  • Mxi2
Purification Method Protein G purified.
UniProt Number
Molecular Weight ~38 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected p38/SAPK2 in 10 µg of A431 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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