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Rb X Neuronal Pentraxin 1

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货号：AB15518

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M ELISA, WB, IHC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB15518
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Neuronal pentraxin 1 Antibody
Alternate Names
  • NPX1
Background Information Neuronal Pentraxins: A new family of putative integral membrane pentraxins or Neuronal pentraxins identified through interaction with a presynaptic snake venom toxin taipoxin. NPX1, NPX2 and NPXR (Neuronal Pentraxin Receptor), the three neuronal pentraxins represent a novel neuronal uptake pathway that may function during synapse formation and remodeling. The N-terminal half of neuronal pentraxins are 20-30% identical to previously identified pentraxins (CRP and SAP), the three neuronal pentraxins are 50% identical to each other and are significantly larger than the classical pentraxins (>50 versus 30kDa), suggesting that they may have additional novel functions. NPX1(Neuronal Pentraxin 1) a 432aa protein in mouse and rat, 430aa in human (chr 17q25). It mediates the uptake of degraded synaptic material which could play an important role in synaptic remodeling, expressed in brain.
References
Product Information
Format Affinity Purified
Presentation Liquid in PBS with 0.1% BSA.
Applications
Application This Anti-Neuronal pentraxin 1 Antibody is validated for use in ELISA, WB, IH for the detection of Neuronal pentraxin 1.
Key Applications
  • ELISA
  • Western Blotting
  • Immunohistochemistry
Application Notes Western blot: 1-10 µg/mL using ECL.
Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL
ELISA: 0.5-1 µg/mL using control peptide.
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide near the N-terminus of mouse NPX1
Host Rabbit
Specificity Neuronal pentraxin 1 (NPX1).
Species Reactivity
  • Mouse
Species Reactivity Note The immunogen sequence is 94% conserved in rat, and 82% in human NPX1.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.
Gene Symbol
  • NPTX1
  • DKFZp686J2446
  • MGC105123
  • NP1
  • NP-I
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q15818 # May mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. Can mediate the neuronal and glial uptake of the snake venom toxin taipoxin (By similarity).
COFACTOR: Binds 2 calcium ions per subunit (By similarity).
SIZE: 432 amino acids; 47122 Da
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle (Potential).
SIMILARITY: SwissProt: Q15818 ## Contains 1 pentaxin domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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