Anti-zDHHC8 (rabbit polyclonal) - 炼石商城

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Anti-zDHHC8 (rabbit polyclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：AB15242

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, R	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB15242
Description	Anti-zDHHC8 Antibody
Alternate Names	Zinc finger DHHC domain-containing protein 8 Zinc finger protein 378 membrane-associated DHHC8 zinc finger protein zinc finger, DHHC domain containing 8 zinc finger, DHHC domain like containing 1 zinc finger, DHHC-type containing 8
Background Information	Six genes in the 1.5 Mb region of chromosome 22 deleted in DiGeorge/22q11 deletion syndrome–Mrpl40, Prodh, Slc25a1, Txnrd2, T10, and Zdhhc8–encode mitochondrial proteins. All six genes are expressed in the brain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1).

References

Product Information
Format	Affinity Purified
Control	Fetal human brain
Presentation	Purified in PBS with 0.05% NaN3

Applications
Application	Anti-zDHHC8 Antibody is an antibody against zDHHC8 for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	Syntheic linear peptide.
Epitope	C-Terminus
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Cat. AB15242 recognizes the C-terminus of zDHHC8.
Species Reactivity	Human Rat
Species Reactivity Note	Human and Rat. Predicted to react with horse, pig, opposum, mouse, cow, xenopus, chimp ,chicken, dog, ape.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	Q9ULC8
Gene Symbol	DHHC-8 EC 2.3.1.- KIAA1292 ZDHHCL1 ZNF378
Purification Method	ImmunoAffinity Purified
UniProt Number	Q9ULC8
UniProt Summary	FUNCTION: Putative palmitoyltransferase involved in glutamatergic transmission By similarity. Catalytic activity Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA. SUBCELLULAR:Cytoplasmic vesicle membrane; Multi-pass membrane proteinPotential. DOMAIN: The DHHC domain is required for palmitoyltransferase activity By similarity. DISEASE: According to Ref.6 and Ref.7, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to Ref.8, Ref.9 and Ref.10, it is not the case. SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. Contains 1 DHHC-type zinc finger.
Molecular Weight	~71 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by western blot in fetal human brain lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

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