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Qiagen 凯杰 Biosharp Omega

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Rb X FXR-B

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号:AB10305

牌:Millipore 密理博

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB10305
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-FXR-B Antibody
Alternate Names
  • Bile acid receptor
  • Farnesoid X-activated receptor
  • Farnesol receptor HRR-1
  • Nuclear receptor subfamily 1 group H member 4
  • Retinoid X receptor-interacting protein 14
  • RXR-interacting protein 14
Background Information The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is known to play a key role in bile acid homeostasis. It does through the regulation of key genes involved in bile acid synthesis, metabolism and transport.
References
Product Information
Format Serum
Presentation Rabbit polyclonal antiserum with 0.1% sodium azide.
Applications
Application Detect FXR-B using this Anti-FXR-B Antibody validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Suggested dilutions:
Western Blotting: 1:5,000
Biological Information
Immunogen Recombinant human FXR-B
Host Rabbit
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • NR1H4
  • BAR
  • FXR
  • HRR1
  • RIP14
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q96RI1 # Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus.
SIZE: 486 amino acids; 55914 Da
SUBUNIT: Heterodimer of NR1H4 and RXR. Interacts with CARM1 and SMARD1.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: SwissProt: Q96RI1 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
Molecular Weight ~56 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting of recombinant human FXR-B.

Western Blotting Analysis: A 1:5,000 dilution of this rabbit polyclonal antiserum detected recombinant human FXR-B.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C for up to 12 months from date of receipt.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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