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Qiagen 凯杰 Biosharp Omega

首页细胞生物学检测Millipore 密理博>

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Human TIMP-1

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货号：CC1062

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number CC1062
Replaces CC1063
Brand Family Chemicon®
Trade Name
  • Chemicon
Description TIMP-1, recombinant, active human
Overview Human TIMP-1, isolated from CHO cells transfected with human TIMP-1 cDNA. A single band at 29kDa is noted by SDS-PAGE.
References
Product Information
Presentation Purified protein in 10 mM Sodium Phosphate, pH 7.3, 0.15M NaCl.
Applications
Key Applications
  • Inhibits Activity/Function
Biological Information
Concentration varies by lot
Specific Activity BIOLOGICAL ACTIVITY: <br /><br />IC50=1.38 x 10E-9M (versus 6.7 x 10E-9 M MMP-1). [Nagai, Y, (1984) Jpn. Jp. Inflam. 4:123-130]
Entrez Gene Number
Entrez Gene Summary This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Gene Symbol
  • TIMP1
  • TIMP
  • FLJ90373
  • CLGI
  • EPA
  • EPO
  • TIMP-1
  • HCI
UniProt Number
UniProt Summary FUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
SIZE: 207 amino acids; 23171 Da
SUBCELLULAR LOCATION: Secreted.
PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.
SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Manufactured by Daiichi Fine Chemical Co., Ltd
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 5 µg
Material Package 5 μg/vial
Transport Information
Supplemental Information
Specifications

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