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Gt X Stub1/CHIP

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货号：AB10000

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Chp ELISA, WB Gt Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB10000
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-CHIP/STUB1 Antibody
Alternate Names
  • CHIP
  • STUB1
Background Information U box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins.
References
Product Information
Format Affinity Purified
Control
  • Positive Control: Highly expressed in brain, heart, skelatal muscle, pancreas and placenta. Weak expression in kidney, liver and lung.
Presentation Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Applications
Application This Anti-CHIP/STUB1 Antibody is validated for use in ELISA, WB for the detection of CHIP/STUB1.
Key Applications
  • ELISA
  • Western Blotting
Biological Information
Immunogen Peptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852.
Host Goat
Species Reactivity
  • Human
  • Chimpanzee
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • STUB1
  • SDCCAG7
  • NY-CO-7
  • HSPABP2
  • UBOX1
  • CHIP
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UNE7 # Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
SIZE: 303 amino acids; 34856 Da
SUBUNIT: Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
PTM: Auto-ubiquitinated (in vitro). & Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: Q9UNE7 # Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.
SIMILARITY: SwissProt: Q9UNE7 ## Contains 3 TPR repeats. & Contains 1 U-box domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at -20°C.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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