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Anti-GADS

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货号：06-983

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 06-983
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-GADS Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%.
Applications
Application Anti-GADS Antibody is an antibody against GADS for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen KLH-conjugated, synthetic peptide corresponding to amino acids 174-188 of murine GADS (GEEIRPSVNRKLSDH)
Host Rabbit
Specificity GADS
Isotype IgG
Species Reactivity
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
Gene Symbol
  • GRAP2
  • GRB2L
  • GADS
  • GRBX
  • GrbX
  • GRBLG
  • GRAP-2
  • Mona
  • P38
  • GRPL
  • Grf40
  • GRID
  • Grf-40
  • OTTHUMP00000028837
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: O75791 # Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
SIZE: 330 amino acids; 37909 Da
SUBUNIT: Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB.
SIMILARITY: SwissProt: O75791 ## Belongs to the GRB2/sem-5/DRK family. & Contains 1 SH2 domain. & Contains 2 SH3 domains.
Molecular Weight 40kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on Jurkat RIPA cell lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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