Anti-RhoG, clone 1F3 B3 E5 (mouse monoclonal) - 炼石商城

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Anti-RhoG, clone 1F3 B3 E5 (mouse monoclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：04-486

品牌：Millipore 密理博

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北京朝阳

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数量：

EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	04-486
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-RhoG Antibody, clone 1F3 B3 E5
Alternate Names	ARHG RHOG ras homolog gene family, member G (rho G) MGC125835 MGC125836
Background Information	RhoG (ARGH) is a member of the Ras super-family of small G-proteins and a member of the Rac subfamily of Rho Family of GTPases. RhoG is a small G-protein (GTPase) who is activated by a GEF (guanine nucleotide exchange factor). The GEF displaces GDP from the binding site of RhoG and allows GTP to bind in it place rendering the protein active. This active RhoG binds downstream effector molecules that include ELMO and DOCK180. RhoG then cleaves GTP to GDP making it inactive. RhoG is believed to be crucial for integrin-mediated Rac activation and cell spreading. RhoG is believed to be active upstream of Rac and work independently of Rac.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2b in storage buffer containing PBS with 0.05% sodium azide.

Applications
Application	Anti-RhoG Antibody, clone 1F3 B3 E5 is an antibody against RhoG for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH synthetic peptide encompassing amino acids CQQDGVKEVFAEAVRAVLNPT (RhoG 160-180)
Clone	clone 1F3 B3 E5
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Recognizes RhoG
Isotype	IgG2bκ
Species Reactivity	Human Mouse Rat
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_001665
Entrez Gene Summary	ARHG is a member of the RAS superfamily of genes, which encode GTP-binding proteins that act in the pathway of signal transduction and play a key role in the regulation of cellular functions.[supplied by OMIM]
Gene Symbol	RHOG ras homolog gene family, member G (rho G) Rho G ARHG MGC125835 MGC125836
Purification Method	Protein G Purified
UniProt Number	P84095
UniProt Summary	FUNCTION: Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. SUBUNIT STRUCTURE:Interacts with SGEF. Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic sidePotential. Sequence similarities: Belongs to the small GTPase superfamily. Rho family.
Molecular Weight	21 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by western blot on NIH/3T3 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at 2-8°C.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

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