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Anti-monomethyl-Histone H4 (Lys20) (rabbit polyclonal IgG)

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货号：07-748

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, Mplex, ICC Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-748
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-monomethyl-Histone H4 (Lys20) Antibody
Alternate Names
  • H4K20me1
  • Histone H4 (mono methyl K20)
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide and 30% glycerol.
Applications
Application Anti-monomethyl-Histone H4 (Lys20) Antibody is a rabbit polyclonal antibody for detection of monomethyl-Histone H4 (Lys20) also known as H4K20me1, Histone H4 (mono methyl K20) & has been validated in WB, Mplex, ICC.
Key Applications
  • Western Blotting
  • Multiplexing
  • Immunocytochemistry
Application Notes Additional Referenced Research Applications:
Immunocytochemistry (cells)
Biological Information
Immunogen KLH-conjugated, branched synthetic peptide corresponding to amino acids 15-25 (AKRHR[me1K]VLRDN) of human Histone H4
Host Rabbit
Specificity monomethylated Histone H4 (Lys20)
Isotype IgG
Species Reactivity
  • Human
Species Reactivity Note Broad species cross-reactivity expected due to sequence conservation
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Gene Symbol
  • HIST2H4B
  • H4/J
  • HIST1H4F
  • HIST1H4L
  • H4FN
  • H4FA
  • H4FH
  • HIST1H4H
  • H4F2
  • H4FM
  • H4/A
  • H4FK
  • H4FG
  • H4/o
  • HIST2H4
  • H4FB
  • H4/K
  • HIST1H4I
  • H4/N
  • HIST1H4B
  • H4FE
  • H4/M
  • HIST1H4E
  • HIST4H4
  • HIST2H4A
  • H4FC
  • H4FI
  • H4/H
  • HIST1H4C
  • H4/G
  • HIST1H4K
  • H4FJ
  • H4FD
  • H4/I
  • H4/B
  • H4/C
  • H4/D
  • HIST1H4J
  • HIST1H4D
  • H4/E
Modifications
  • Methylation
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 103 amino acids; 11367 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
Molecular Weight 10kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C from date of shipment
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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