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Rb X MAP1LC3 C

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货号：AB15414

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R WB, ICC, IHC Rb Serum Polyclonal Antibody
Description
Catalogue Number AB15414
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-MAP1LC3 C Antibody
Alternate Names
  • Microtubule-associated proteins 1A/1B light chain 3C
  • MAP1A/1B LC3 C
  • MAP1 LC3
  • LC3 C
Background Information Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. The human MAP1LC3 protein is homologous with the rat Map1LC3 and with yeast APG8. These proteins are likely to be involved in the formation of autophagosomal vacuoles (autophagosomes).
References
Product Information
Format Serum
Presentation Lyophilized. Reconstitute with 50 uL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
Applications
Application This Anti-MAP1LC3 C Antibody is validated for use in WB, IC, IH for the detection of MAP1LC3 C.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Western blot: 1:100-1:1,000
Immunocytochemistry: 1:100-1:1,000
Immunohistochemistry: 1:100-1:1,000
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide corresponding to a region within the N-terminus of human MAP1LC3 C protein.
Host Rabbit
Specificity MAP1LC3 C [Microtubule-associated proteins 1A/1B light chain 3C, MAP1A/1B LC3 C, MAP1 LC3, LC3 C].
Species Reactivity
  • Human
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MAP1LC3C
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9BXW4 # Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity).
SIZE: 147 amino acids; 16852 Da
SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane; Lipid- anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes.
TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary.
PTM: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
SIMILARITY: SwissProt: Q9BXW4 ## Belongs to the MAP1 LC3 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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