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Ras Assay Reagent (Raf-1 RBD, agarose)

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货号：14-278

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-278
Brand Family Upstate
Trade Name
  • Upstate
Description Ras Assay Reagent (Raf-1 RBD, agarose)
Overview GST fusion-protein, corresponding to Ras Binding Domain of Raf-1, provided bound to glutathione agarose.
References
Product Information
Applications
Key Applications
  • Enzyme Assays
Biological Information
Source Human Ras Binding Domain (RBD, residues 1-149) of Raf-1, expressed in E. coli.
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM]
Gene Symbol
  • MRAS
  • RRAS3
  • M-RAS
  • FLJ42964
  • R-RAS3
  • M-RAs
UniProt Number
UniProt Summary FUNCTION: SwissProt: O14807 # May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.
SIZE: 208 amino acids; 23846 Da
SUBUNIT: Interacts with RGL3 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
TISSUE SPECIFICITY: Expression highly restricted to the brain and heart.
SIMILARITY: SwissProt: O14807 ## Belongs to the small GTPase superfamily. Ras family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by Affinity Precipitation/Immunoblot Analysis
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at -20°C
Packaging Information
Material Size 600 µg
Transport Information
Supplemental Information
Specifications

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