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Chk X PLP Polyclonal Antibody

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货号：AB15454

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M ICC, IHC Ch Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB15454
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Proteolipid Protein Antibody
Alternate Names
  • PLP
References
Product Information
Format Affinity Purified
Presentation Liquid in PBS, pH 7.2 with 0.02% sodium azide.
Applications
Application Detect Proteolipid Protein using this Anti-Proteolipid Protein Antibody validated for use in IC, IH.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Immunohistochemistry: 1:100-1:200 using 2% paraformaldehyde fixed tissue.
Immunocytochemistry: 1:100-1:200 using 2% paraformaldehyde fixed cells.
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide corresponding to human/mouse PLP protein.
Host Chicken
Specificity PLP [Proteolipid Protein]
Species Reactivity
  • Mouse
Species Reactivity Note Other species have not yet been tested. It is expected that the antibody will also react with human due to immunogen sequence similarity.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene.
Gene Symbol
  • PLP1
  • lipophilin
  • MMPL
  • PLP/DM20
  • PLP
  • PMD
  • SPG2
  • Lipophilin
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P60201 # This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
SIZE: 277 amino acids; 30077 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P60201 # Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked neurologic disorder of myelin metabolism. It is characterized by early impairment of motor development (during the first three months of life) and, later, by the development of abnormal movements and progressive spastic paraplegia. & Defects in PLP1 are the cause of spastic paraplegia type 2 (SPG2) [MIM:312920]. SPG2 is a form of X-linked hereditary spastic paraplegia (HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Additional features include nystagmus, dysarthria and mental retardation, that are found in the complicated form of spastic paraplegia.
SIMILARITY: SwissProt: P60201 ## Belongs to the myelin proteolipid protein family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
Packaging Information
Material Size 500 µL
Transport Information
Supplemental Information
Specifications

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