PKBB/AKT2(NO PH DOMAIN) 10UG - 炼石商城

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PKBB/AKT2(NO PH DOMAIN) 10UG

市场价：: 0.00

促销价：: ¥0.00

货号：14-339

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

Description
Catalogue Number	14-339
Brand Family	Upstate
Trade Name	Upstate
Description	Akt2/PKBβ (δPH, S474D) Protein, active, 10 µg
Overview	Recombinant human PKBβ, residues 120-481, S474D, containing an N-terminal His6 tag; activated by PDK1.

References

Product Information

Applications
Application	Active, recombinant human PKBβ, residues 120-481, S474D, containing an N-terminal His6 tag, activated by PDK1. For use in Kinase Assays.
Key Applications	Kinase Assay

Biological Information
Source	Expressed by baculovirus in Sf21 insect cells.
Specific Activity	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number	NM_001626.3
Entrez Gene Summary	This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
Gene Symbol	AKT2 RAC-BETA PRKBB PKBBETA RAC-PK-beta
Protein Target	Akt2/PKBβ
Purification Method	Ni²⁺/NTA-agarose & heparin-Sepharose™ chromatography
Target Sub-Family	AGC
UniProt Number	P31751
UniProt Summary	FUNCTION: SwissProt: P31751 # General protein kinase capable of phosphorylating several known proteins. SIZE: 481 amino acids; 55769 Da TISSUE SPECIFICITY: In all human cell types so far analyzed. DISEASE:SwissProt: P31751 # Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas. SIMILARITY: SwissProt: P31751 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain.
Molecular Weight	42.8kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by phosphorylation of Crosstide
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	1 year at -70°C

Packaging Information
Material Size	10 µg
Material Package	Also available in 250 µg size --call for pricing and availability and reference catalog number 14-339M when ordering the 250 µg size.

Transport Information

Supplemental Information

Specifications

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