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Milli-Mark™ Anti-MAPK 1/2 (ERK), Alexa Fluor® 647 Conjugate

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号:FCABS165A6

牌:Millipore 密理博

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Replacement Information

重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC Rb AlexaFluor®647 Polyclonal Antibody
Description
Catalogue Number FCABS165A6
Trade Name
  • Milli-Mark
Description Milli-Mark™ Anti-MAPK 1/2 (tERK) Antibody, Alexa Fluor 647 Conjugate
Alternate Names
  • Extracellular signal-regulated kinase 1
  • ERK-1
  • Insulin-stimulated MAP2 kinase
  • Mitogen-activated protein kinase 1
  • MAP kinase 1
  • MAPK 1
  • p44-ERK1
  • ERT2
  • MAP kinase isoform p44
  • p44
  • MAPK
  • Microtubule-associated protein 2 kinase
  • MNK1
Background Information The extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called MAPK1 and MAPK2, are members of the Mitogen Activated Protein Kinase (MAPK) family of proteins found in all eukaryotes. Because the 44 kDa ERK1 and the 42 kDa ERK2 are highly homologous and both function in the same protein kinase cascade, the two proteins are often referred to collectively as ERK1/2 or MAPK1/2. The MAPK1/2 signaling cascade has been shown to be a critical regulator of cell differentiation, cell physiology and neuronal function. Aberrant control of MAPK1/2 activity has been implicated in a variety of pathological conditions, including cancer and autoimmune diseases, and efficient study methods are in demand.
References
Product Information
Format AlexaFluor®647
Control
  • Jurkat cells
Presentation Purified rabbit polyclonal antibody conjugated to Alexa Fluor 647 in PBS buffer with 15mg/mL BSA and 0.1% Sodium Azide
Applications
Application Milli-Mark Anti-MAPK 1/2 (tERK) Antibody, Alexa Fluor 647 Conjugate detects level of MAPK 1/2 (tERK) & has been published & validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to rat MAPK 1/2 at the C-terminus.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Antibody recognizes MAPK1/2. C-terminus.
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Kinase involved in intracellular signalling; component of Mapk signalling pathway [RGD]
Gene Symbol
  • MAPK1
  • p38
  • ERK
  • P42MAPK
  • ERK2
  • p40
  • PRKM1
  • p41mapk
  • PRKM2
  • MAPK2
  • p42-MAPK
  • p41
  • ERK-2
  • ERT1
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4) By similarity
Molecular Weight 43 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using Jurkat cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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