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p38/SAPK2 (SB202190)

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货号：19-134

品牌：Millipore 密理博

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Replacement Information

重要规格表

Uni Prot Number
Q15759
Description
Catalogue Number 19-134
Brand Family Upstate
Trade Name
  • Upstate
Description p38/SAPK2 Inhibitor (SB 202190)
References
Product Information
Presentation C20H14FN3O
Applications
Application The p38/SAPK2 Inhibitor (SB 202190) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.
Key Applications
  • Kinase Assay
Application Notes Potent inhibitor of p38 alpha/SAPK2a and p38 beta/SAPK2b kinases.
Biological Information
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
Gene Symbol
  • MAPK11
  • p38-2
  • p38b
  • P38B
  • p38Beta
  • p38beta2
  • SAPK2B
  • SAPK2
  • PRKM11
  • P38BETA2
Protein Target p38/SAPK2
Target Sub-Family CMGC
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
COFACTOR: Magnesium (By similarity).
SIZE: 364 amino acids; 41357 Da
TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated in a kinase assay as an inhibitor.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 3 years at -20°C
Packaging Information
Material Size 1 mg
Transport Information
Supplemental Information
Specifications

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