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Anti-MCH-R2 (Chicken Polyclonal)

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货号：AB5861

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R IHC Ch Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5861
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, CT
Alternate Names
  • MCH-R2
Background Information Melanin Concentrating Hormone Receptor type 2 (MCH-R2) is a G-protein coupled receptor with seven transmembrane domains. MCH-R2 is 340 amino acids in length (approximately 39 kDa) and shares approximately 38% amino acid identity with MCH-R1. Like MCH-R1, it binds MCH with high affinity. However, reports indicate that signaling through this receptor is pertussis insensitive, contrary to MCH-R1. Expression of MCH-R2 mRNA is restricted to several regions of the brain, including the arcuate nucleus and the ventral medial hypothalamous (Sailer, 2001).
References
Product Information
Format Affinity Purified
Presentation Affinity purified immunoglobulin in PBS, pH 7.2 containing 0.1% sodium azide.
Applications
Application This Anti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, C-terminus is validated for use in IH for the detection of Melanin Concentrating Hormone Receptor Type 2.
Key Applications
  • Immunohistochemistry
Application Notes Immunohistochemistry: 1 μg/mL on brain cryostat sections. The antibody stains extensively through the brain and is particularly striking in the ganglionic layer of the cerebellum.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic 16 amino acid peptide corresponding to the intracellular carboxy-terminus of human MHC-R2.
Epitope intracellular, C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Chicken
Specificity Human Melanin Concentrating Hormone Receptor Type 2 (MCH-R2). The antibody has been used to stain tissues from rat and mouse as well as human.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MCHR2
  • MCH-2R
  • S643b
  • MCH2
  • MCHR-2
  • OTTHUMP00000043201
  • SLT
  • GPR145
  • GPRv17
  • MCH2R
  • MCH-R2
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q969V1 # Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
SIZE: 340 amino acids; 38849 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.
SIMILARITY: SwissProt: Q969V1 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. The antibody can also be diluted 1:1 with glycerol (ACS grade or better) for added stability. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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