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Rb GABA-A Receptor Gamma 2 Subunit

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货号：AB5954

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R ELISA, IP, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB5954
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-GABA A Receptor γ2 Antibody
References
Product Information
Format Serum
Presentation Rabbit serum. Liquid.
Applications
Application Detect GABA A Receptor γ2 using this Anti-GABA A Receptor γ2 Antibody validated for use in ELISA, IP & WB.
Key Applications
  • ELISA
  • Immunoprecipitation
  • Western Blotting
Application Notes Western blot: 1:500-1:1,000. Recognizes a 45-47 kDa protein.

Immunoprecipitation

ELISA

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide from rat GABA-A receptor gamma 2 subunit from the N-terminus.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity GABA-A receptor gamma 2 subunit. No known cross reactivity with other gamma GABA-A receptor or alpha and beta subunits. The immunogen sequence is identical in human, mouse and bovine.
Species Reactivity
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.
Gene Symbol
  • GABRG2
  • GABA
  • CAE2
  • ECA2
  • GEFSP3
UniProt Number
UniProt Summary FUNCTION: SwissProt: P18507 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SIZE: 467 amino acids; 54162 Da
SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with GABARAP.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
PTM: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability (By similarity).
DISEASE: SwissProt: P18507 # Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2) [MIM:607681]. ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile seizures [MIM:121210]. A febrile seizure is defined as a convulsion event in infancy or childhood, usually occurring between 3 months and 5 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. & Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3) [MIM:604233]. This autosomal dominant disorder is characterized by febrile seizures in children and afebrile seizures in adults. Penetrance is incomplete and a large intrafamilial variability of the phenotype is observed. & Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]. SMEI is a rare disorder characterized by normal development before onset, seizures beginning in the first year of life in the form of generalized or unilateral febrile clonic seizures, secondary appearance of myoclonic seizures, and occasionally partial seizures. It is associated with ataxia, slowed psychomotor development, and mental decline.
SIMILARITY: SwissProt: P18507 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
MISCELLANEOUS: This subunit carries the benzodiazepine binding site.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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