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Ms X gC1q-R/p33 Complement Receptor

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货号：MAB1160

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M ELISA, FC, IP, WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB1160
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-gC1q-R/p33 Antibody, CT, aa 204-218, clone 74.5.2
Alternate Names
  • ASF/SF2-associated protein p32
  • Glycoprotein gC1qBP
  • Hyaluronan-binding protein 1
  • Mitochondrial matrix protein p32
  • gC1q-R protein
  • p33
  • C1qBP
References
Product Information
Format Purified
Presentation Purified immunoglobulin. Liquid in 0.02M PBS pH 7.6, 0.25M NaCl with 0.1% sodium azide.
Applications
Application This Anti-gC1q-R/p33 Antibody, C-terminus, aa 204-218, clone 74.5.2 is validated for use in ELISA, FC, IP, WB for the detection of gC1q-R/p33.
Key Applications
  • ELISA
  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
Application Notes Western blot

Immunoprecipitation

ELISA

FACS

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Recombinant human gC1q-R.
Epitope C-terminus, aa 204-218
Clone 74.5.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Recognizes the mature form and truncated forms of gC1q-R/p33 complement receptor. Antibody is directed against the carboxyl-terminus of the receptor (residues 204-218), a portion of the molecule specifies interaction with HK and Factor XII and blocks binding of HK to gC1q-R.
Isotype IgG1κ
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.
Gene Symbol
  • C1QBP
  • GC1QBP
  • HABP1
  • SF2P32
UniProt Number
UniProt Summary Complement component 1 Q subcomponent-binding protein, mitochondrial (UniProt: Q07021: also known as SF/SF2-associated protein p32, Glycoprotein gC1qBP, C1qBP, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, gC1q-R protein, p33) is encoded by the C1QBP (also known as GC1QBP, HABP1, SF2P32) gene (Gene ID: 708) in human. C1qBP is a multifunctional and multi-compartmental homotrimeric protein that is involved in inflammation and infection processes. It is also reported to play a role in ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. C1qBP is synthesized with a transit peptide (aa 1-73) that is required for its mitochondrial localization. It is expressed on cell surface of peripheral blood cells and its expression is enhanced upon platelet and monocyte activation. It serves as a putative receptor for C1q and specifically binds to the globular "heads" of C1q thus inhibiting C1 activity. Its C1q binding region is localized to amino acids 76-93. Its receptor function is through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1, it also acts as a high affinity receptor for kininogen-1/HMWK. The secreted form of C1qBP is reported to enhance both extrinsic and intrinsic coagulation pathways.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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