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Milli-Mark™ Anti-CD79ß-FITC clone SN8

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货号：FCMAB209F

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC M FITC Monoclonal Antibody
Description
Catalogue Number FCMAB209F
Trade Name
  • Milli-Mark
Description Milli-Mark™ Anti-CD79β-FITC Antibody, clone SN8
Alternate Names
  • B-cell antigen receptor complex-associated protein beta chain
  • Ig-beta
  • B-cell-specific glycoprotein B29
  • Immunoglobulin-associated B29 protein
Background Information CD79beta is restricted to the B-cell lineage, and is found in pro-B cells before Ig heavy-chain gene rearrangement but after CD79alpha expression. The antibody reacts with an epitope on the extracellular domain of CD79 (Yoshida, 1995). Anti-CD79beta, SN8, was included in the Fifth International Workshop and Conference on Human Leucocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with CD79beta (Engel, 1995; Persin, 1995).
References
Product Information
Format FITC
Control
  • Human Lymphocytes
Presentation Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Applications
Application Milli-Mark Anti-CD79β-FITC Antibody, clone SN8 detects level of CD79β & has been published & validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Clone SN8
Host Mouse
Specificity Antibody recognizes Human CD79b antigen.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method Protein A Purfied
UniProt Number
UniProt Summary Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are a cause of hypogammaglobulinemia immunodeficiency and reduced B cells. Hypogammaglobulinemia is an immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood. The disorder results in a failure of B cell development in patients with immunodeficiency and is associated with a markedly reduced but not absent B cells.
Molecular Weight 36 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using human lymphocytess
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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