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Anti-K+/CI-Cotransporter (KCC2), clone N1/12 (mouse monoclonal)

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货号：MABN88

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, H, R IHC M Purified Monoclonal Antibody
Description
Catalogue Number MABN88
Description Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12
Alternate Names
  • Electroneutral potassium-chloride cotransporter 2
  • Erythroid K-Cl cotransporter 2
  • Neuronal K-Cl cotransporter
  • electroneural potassium-chloride cotransporter 2
  • solute carrier family 12
  • potassium-chloride transporter), member 5
Background Information KCC2 is a member of the cation-chloride cotransporter gene family. It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain. KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior.
References
Product Information
Format Purified
Control
  • Rat cortex area A-3 tissue
Presentation Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application Detect K+/Cl-Cotransporter (KCC2) using this Anti-K+/Cl-Cotransporter (KCC2) Antibody, clone N1/12 validated for use in IH.
Key Applications
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected KCC2 in rat hypothalamus tissue.
Biological Information
Immunogen Recombinant protein corresponding to rat KCC2.
Epitope Unknown
Clone N1/12
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes KCC2
Isotype IgG2aκ
Species Reactivity
  • Rat
  • Human
  • Rat
Species Reactivity Note Demonstrated to react with rat. Shown by an independent laboratory to react in human and mouse tissue. (UC Davis/NIH NeuroMab Facility Department of Neurobiology, Physiology and Behavior)
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Neuronal specific potassium-chloride cotransporter isoform; may play a role in response to neuronal injury [RGD].
Gene Symbol
  • SLC12A5
  • KIAA1176
  • hKCC2
  • KCC2
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl- homeostasis in neurons. Necessary for the ontogenic change in response to gamma-aminobutyric acid (GABA) from depolarization to hyperpolarization during neuronal development.

SUBUNIT STRUCTURE: Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity).

SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

TISSUE SPECIFICTY: Highly expressed in brain. Not detected in other tissues. Highly expressed in pyramidal neurons and in neurons throughout the cortex, hippocampus, the granular layer of the cerebellum and in groups of neurons throughout the brainstem. Barely detectable in dorsal-root ganglions.

DEVELOPMENTAL STAGE: Detected in thalamus, but not in hippocampus and neocortex at E20. At birth barely detectable in hippocampus. Expression increases steeply from day 5 to day 9 and then stabilizes at adult levels.

SEQUENCE SIMILARITIES: Belongs to the SLC12A transporter family.
Molecular Weight 126 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in rat cortex area A-3 tissue.

Immunohistochemistry Analysis: 1:300 dilution of this antibody detected KCC2 in rat cortex area A-3 tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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